The St. Thomas Tommies face the formidable North Dakota State Bison on Saturday, November 22, 2025. Kickoff is set for 2:30 p.m. CT at the Fargodome in Fargo. This marks the first meeting between the programs in nearly six decades. The top-ranked Bison enter as massive favorites against the injury-plagued Tommies.
The matchup represents a colossal challenge for St. Thomas. According to the Twin Cities Pioneer Press, the Tommies will be without starting quarterback Andy Peters and multiple other key starters. Meanwhile, NDSU boasts an unblemished 11-0 record and the nation’s top-ranked FCS defense.
Historical Context and a Lopsided Series
This game is the 24th all-time meeting between these two schools. The Bison hold a commanding 14-7-2 lead in the series. Their last matchup was all the way back in 1966.
That long gap adds a unique layer to this contest. For St. Thomas head coach Glenn Caruso, the game is also a personal return. He began his coaching career as a graduate assistant at NDSU in 1997.
Injury Report Decimates Tommies’ Chances
The injury situation for St. Thomas is severe. Graduate transfer quarterback Andy Peters is officially out. Several other defensive and offensive starters will also miss the game.
Coach Caruso acknowledged the difficult reality. He stated the team will simply “play those who are able and hope for the best.” This shortage of personnel creates a nearly insurmountable obstacle against an elite opponent.
In stark contrast, North Dakota State has no significant injuries reported. Their full complement of starters is expected to play. This health disparity further tilts the scales.
Analyzing NDSU’s Overwhelming Dominance
North Dakota State’s credentials are impeccable. They are the defending FCS national champions, having won their tenth title in January 2025. Their average margin of victory this season is staggering.
Caruso himself called this Bison squad potentially the best in the program’s storied history. Their defense allows a mere 12.1 points per game. Their offense, led by an elite quarterback and NFL-caliber skill players, averages over 40 points.
The betting markets reflect this dominance. NDSU is favored by more than 30 points in most outlets. Moneyline odds heavily favor the Bison, making a St. Thomas victory a monumental longshot.
For St. Thomas, keeping this game competitive would be a moral victory. The final St. Thomas vs North Dakota State prediction must account for a wide talent gap exacerbated by injuries. The Tommies’ focus will be on execution and building experience for their Division I future.
A quick knowledge drop for you:
Why is St. Thomas such a big underdog?
St. Thomas is missing several key starters, including their starting quarterback. They are also facing the undefeated, top-ranked team in the country which boasts the best defense in the FCS. The combination of injuries and opponent strength creates a massive challenge.
What is the historical record between these teams?
North Dakota State leads the all-time series 14 wins to 7 losses, with 2 ties. This will be their first meeting since 1966, ending a hiatus of nearly 60 years between games.
How can I watch the St. Thomas vs. NDSU game?
The game kicks off at 2:30 p.m. Central Time on Saturday, November 22. Broadcast details are typically announced closer to game day, with coverage often on ESPN+ or other regional sports networks.
What did Coach Caruso say about NDSU?
Glenn Caruso stated this NDSU team might be the best in the program’s championship-filled history. He specifically highlighted their dominant defense as the best in the nation “by a lot.”
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